In 1424 the manors of Alfauir and Rafalet de Bonamira were finally donated to the monastery. These, together with many other donations, were left by Alfonso the Old in his will. To these were added the Orriols Manor, which came from the inheritance of Pere Orriols in 1475, and the Tavernes Blanques Manors, acquired in 1515.
During the 16th Century, Sant Jeroni enjoyed the protection of the Dukes of Gandia, the Borja family; the Duchess María Enríquez was the principal protector of the monastery. Towards the end of this century, in 1586, Philip II of Spain paid a visit lasting several days, accompanied by the heir to the throne and his beloved daughter, Isabel Clara Eugenia. Another royal visit was hosted on the occasion of the marriage between Philip III of Spain and Margaret of Austria. These visits represent hard proof of the royal protection enjoyed by the Hieronymite order right from its beginnings, especially that bestowed by the House of Hapsburg. Prior to this, both the order and Sant Jeroni de Cotalba were also favoured by the Aragonese monarchs, as Martin of Aragon and Ferdinand II of Aragon made numerous donations and instituted exemptions from tributes.
Throughout the 17th Century, and particularly during the course of the following hundred years, there was a gradual relaxation of the customs practised by the members of the community. This led to the reform of the monastery’s governance in 1743.
A notable event occurred in 1751 when the monks were plagued by an epidemic and commended themselves to the Onil Virgin of Health, whose image was carried to the monastery. The intercession of this figure of the Virgin Mary was so decisive in curing the monks that they built a chapel in her honour, and their dedication led to her being made the patron Saint of Rótova.
This moral and spiritual crisis is reflected in the general crisis suffered by the monastery in the 18th Century. Despite architectural improvements, its economic situation was not as prosperous as expected and the monks resorted to charging feudal rent and collecting harvest taxes. The eighteenth century crisis seemed to affect all facets of the monastery, with its economic decline being mirrored by that of its ideological apparatus that maintained the status quo with society.